Drug interactions
Canagliflozin + Eprosartan-hydrochlorothiazide
Severity: Moderate
Canagliflozin and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin has an osmotic diuretic effect that adds to the diuresis of hydrochlorothiazide and the renal hemodynamic effects of eprosartan. This raises the risk of volume depletion, hypotension and acute kidney injury, particularly in older or frail patients.
What this interaction means in plain words
Canagliflozin and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects, with reduced intraglomerular pressure from angiotensin receptor blockade combined with SGLT2-induced volume contraction.
What to do
Assess volume status and renal function before starting canagliflozin and recheck within the first weeks. Consider lowering the thiazide dose if the patient becomes volume depleted or hypotensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Canagliflozin and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin has an osmotic diuretic effect that adds to the diuresis of hydrochlorothiazide and the renal hemodynamic effects of eprosartan. This raises the risk of volume depletion, hypotension and acute kidney injury, particularly in older or frail patients.
How serious is the interaction between Canagliflozin and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before starting canagliflozin and recheck within the first weeks. Consider lowering the thiazide dose if the patient becomes volume depleted or hypotensive.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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