Drug interactions
Canagliflozin + Fosinopril
Severity: Moderate
Canagliflozin and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin has been associated with small increases in serum potassium, particularly in patients with renal impairment, and ACE inhibitors also raise potassium. The combination may contribute to hyperkalemia. Both drugs may also cause volume depletion and affect renal function.
What this interaction means in plain words
Canagliflozin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Fosinopril belongs to Cardiovascular.
Why it happens
ACE inhibition reduces aldosterone-mediated potassium excretion while canagliflozin may modestly raise potassium and reduce volume and renal perfusion.
What to do
Monitor serum potassium and renal function after starting canagliflozin. Assess volume status and adjust therapy if hyperkalemia or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Fosinopril?
MediHelp rates the interaction as moderate. Canagliflozin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin has been associated with small increases in serum potassium, particularly in patients with renal impairment, and ACE inhibitors also raise potassium. The combination may contribute to hyperkalemia. Both drugs may also cause volume depletion and affect renal function.
How serious is the interaction between Canagliflozin and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function after starting canagliflozin. Assess volume status and adjust therapy if hyperkalemia or volume depletion develops.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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