Drug interactions
Canagliflozin + Gliclazide
Severity: Moderate
Canagliflozin and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin lowers glucose independent of insulin, and when added to a sulfonylurea such as gliclazide it increases the risk of hypoglycemia. Volume depletion from the SGLT2 inhibitor may add to patient vulnerability.
What this interaction means in plain words
Canagliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Gliclazide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-driven insulin secretion plus SGLT2-mediated urinary glucose excretion.
What to do
Consider lowering the gliclazide dose when starting canagliflozin and monitor blood glucose. Educate the patient on hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Gliclazide?
MediHelp rates the interaction as moderate. Canagliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin lowers glucose independent of insulin, and when added to a sulfonylurea such as gliclazide it increases the risk of hypoglycemia. Volume depletion from the SGLT2 inhibitor may add to patient vulnerability.
How serious is the interaction between Canagliflozin and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the gliclazide dose when starting canagliflozin and monitor blood glucose. Educate the patient on hypoglycemia recognition.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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