Drug interactions
Canagliflozin + Glipizide-metformin
Severity: Moderate
Canagliflozin and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin lowers glucose independently of insulin and, when added to glipizide, raises the risk of hypoglycemia. Metformin contributes little to this risk.
What this interaction means in plain words
Canagliflozin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Glipizide-metformin belongs to Endocrine.
Why it happens
Additive glucose lowering, with SGLT2 inhibition added to sulfonylurea-driven insulin secretion.
What to do
Consider lowering the glipizide dose when starting canagliflozin and monitor blood glucose. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Glipizide-metformin?
MediHelp rates the interaction as moderate. Canagliflozin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin lowers glucose independently of insulin and, when added to glipizide, raises the risk of hypoglycemia. Metformin contributes little to this risk.
How serious is the interaction between Canagliflozin and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glipizide dose when starting canagliflozin and monitor blood glucose. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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