Drug interactions
Canagliflozin + Glyburide-metformin
Severity: Moderate
Canagliflozin and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin adds glucose lowering to glyburide, raising the risk of hypoglycemia. Volume depletion from the SGLT2 inhibitor may add to risk in older or frail patients.
What this interaction means in plain words
Canagliflozin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Glyburide-metformin belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from insulin secretion by sulfonylurea plus SGLT2-mediated glycosuria.
What to do
Consider lowering the glyburide dose when adding canagliflozin. Monitor blood glucose and volume status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Glyburide-metformin?
MediHelp rates the interaction as moderate. Canagliflozin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin adds glucose lowering to glyburide, raising the risk of hypoglycemia. Volume depletion from the SGLT2 inhibitor may add to risk in older or frail patients.
How serious is the interaction between Canagliflozin and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when adding canagliflozin. Monitor blood glucose and volume status.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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