Drug interactions
Canagliflozin + Hydrochlorothiazide-telmisartan
Severity: Moderate
Canagliflozin and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin adds diuretic and blood pressure lowering effects to the thiazide and ARB, raising the risk of volume depletion, hypotension and acute kidney injury. Potassium changes are variable.
What this interaction means in plain words
Canagliflozin and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive osmotic diuresis and natriuresis from SGLT2 inhibition plus thiazide diuresis and ARB-mediated reduction in glomerular pressure.
What to do
Assess volume status and renal function before and after starting; consider lowering the diuretic dose in at-risk patients and monitor potassium and creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Canagliflozin and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin adds diuretic and blood pressure lowering effects to the thiazide and ARB, raising the risk of volume depletion, hypotension and acute kidney injury. Potassium changes are variable.
How serious is the interaction between Canagliflozin and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting; consider lowering the diuretic dose in at-risk patients and monitor potassium and creatinine.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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