Drug interactions
Canagliflozin + Lisinopril
Severity: Moderate
Canagliflozin and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin has been associated with potassium elevations, particularly in patients with renal impairment or on RAAS inhibitors. With lisinopril, hyperkalemia risk rises. Volume depletion and reduced renal function can further contribute.
What this interaction means in plain words
Canagliflozin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
ACE inhibition lowers aldosterone-driven potassium excretion, and canagliflozin may add to potassium elevation through hemodynamic and renal effects.
What to do
Monitor serum potassium and renal function after starting canagliflozin. Correct volume depletion and review other potassium-raising drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Lisinopril?
MediHelp rates the interaction as moderate. Canagliflozin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin has been associated with potassium elevations, particularly in patients with renal impairment or on RAAS inhibitors. With lisinopril, hyperkalemia risk rises. Volume depletion and reduced renal function can further contribute.
How serious is the interaction between Canagliflozin and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function after starting canagliflozin. Correct volume depletion and review other potassium-raising drugs.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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