Drug interactions
Canagliflozin + Metformin-repaglinide
Severity: Moderate
Canagliflozin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin lowers blood glucose independently of insulin, and adding it to the repaglinide component of this combination raises the risk of hypoglycemia. Metformin carries little hypoglycemic risk itself, so the secretagogue is the main concern.
What this interaction means in plain words
Canagliflozin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT2 inhibition-induced glycosuria and repaglinide-stimulated insulin secretion.
What to do
Consider lowering the repaglinide dose when starting canagliflozin. Monitor blood glucose and renal function, and counsel on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Canagliflozin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin lowers blood glucose independently of insulin, and adding it to the repaglinide component of this combination raises the risk of hypoglycemia. Metformin carries little hypoglycemic risk itself, so the secretagogue is the main concern.
How serious is the interaction between Canagliflozin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the repaglinide dose when starting canagliflozin. Monitor blood glucose and renal function, and counsel on hypoglycemia symptoms.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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