Drug interactions
Canagliflozin + Moexipril
Severity: Moderate
Canagliflozin and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and canagliflozin can affect potassium and renal function. Canagliflozin has been associated with hyperkalemia, mainly in patients with renal impairment or on RAAS inhibitors, and both can cause volume depletion and hypotension.
What this interaction means in plain words
Canagliflozin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
Additive effects on potassium handling plus volume depletion from SGLT2 inhibition that, together with ACE inhibition, reduces glomerular filtration pressure.
What to do
Monitor serum potassium, creatinine and blood pressure after initiation. Correct volume depletion and consider reducing the diuretic or antihypertensive dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Moexipril?
MediHelp rates the interaction as moderate. Canagliflozin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ACE inhibitors and canagliflozin can affect potassium and renal function. Canagliflozin has been associated with hyperkalemia, mainly in patients with renal impairment or on RAAS inhibitors, and both can cause volume depletion and hypotension.
How serious is the interaction between Canagliflozin and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure after initiation. Correct volume depletion and consider reducing the diuretic or antihypertensive dose.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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