Drug interactions
Canagliflozin + Nateglinide
Severity: Moderate
Canagliflozin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin combined with nateglinide increases the risk of hypoglycemia. Labeling advises considering a lower dose of the insulin secretagogue.
What this interaction means in plain words
Canagliflozin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from SGLT2-mediated glucosuria and nateglinide-stimulated insulin secretion.
What to do
Consider lowering the nateglinide dose when adding canagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Nateglinide?
MediHelp rates the interaction as moderate. Canagliflozin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin combined with nateglinide increases the risk of hypoglycemia. Labeling advises considering a lower dose of the insulin secretagogue.
How serious is the interaction between Canagliflozin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the nateglinide dose when adding canagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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