Drug interactions
Canagliflozin + Sacubitril-valsartan
Severity: Moderate
Canagliflozin and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin is not a well-established cause of hyperkalemia and the legacy rationale is weak. The practical concern is additive volume depletion, hypotension and renal function changes when an SGLT2 inhibitor is added to an angiotensin receptor blocker. Potassium rises have been seen with canagliflozin in some renally impaired patients.
What this interaction means in plain words
Canagliflozin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on volume status, blood pressure and renal hemodynamics; potassium effect is modest.
What to do
Monitor blood pressure, renal function and serum potassium after initiation. Correct volume depletion and consider reducing diuretic doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin and Sacubitril-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Canagliflozin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin is not a well-established cause of hyperkalemia and the legacy rationale is weak. The practical concern is additive volume depletion, hypotension and renal function changes when an SGLT2 inhibitor is added to an angiotensin receptor blocker. Potassium rises have been seen with canagliflozin in some renally impaired patients.
How serious is the interaction between Canagliflozin and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and serum potassium after initiation. Correct volume depletion and consider reducing diuretic doses if hypotension occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
