Drug interactions
Canagliflozin + Triamterene
Severity: Moderate
Canagliflozin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a potassium-sparing diuretic that can raise serum potassium. Canagliflozin has been associated with small potassium increases in some patients, particularly those with renal impairment, so combined use may add to hyperkalemia risk. Canagliflozin also adds diuretic and volume-depleting effects.
What this interaction means in plain words
Canagliflozin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene blocks distal tubular sodium channels reducing potassium excretion, while canagliflozin may modestly raise potassium and causes additive volume depletion.
What to do
Monitor serum potassium, renal function and volume status after starting or adjusting either drug. Reduce or stop triamterene if potassium rises or renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Triamterene?
MediHelp rates the interaction as moderate. Canagliflozin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene is a potassium-sparing diuretic that can raise serum potassium. Canagliflozin has been associated with small potassium increases in some patients, particularly those with renal impairment, so combined use may add to hyperkalemia risk. Canagliflozin also adds diuretic and volume-depleting effects.
How serious is the interaction between Canagliflozin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and volume status after starting or adjusting either drug. Reduce or stop triamterene if potassium rises or renal function deteriorates.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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