Drug interactions
Canagliflozin + Valsartan
Severity: Moderate
Canagliflozin and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin does not generally raise potassium significantly, though it has been linked with small rises in some patients. Combined with valsartan, volume depletion and hypotension and changes in renal function are the more relevant concerns.
What this interaction means in plain words
Canagliflozin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Valsartan belongs to Cardiovascular.
Why it happens
Additive volume reduction and hemodynamic effects on glomerular filtration from SGLT2 inhibition plus angiotensin receptor blockade.
What to do
Monitor blood pressure, volume status, renal function and potassium after starting canagliflozin, and reduce the diuretic or antihypertensive dose if volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Valsartan?
MediHelp rates the interaction as moderate. Canagliflozin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin does not generally raise potassium significantly, though it has been linked with small rises in some patients. Combined with valsartan, volume depletion and hypotension and changes in renal function are the more relevant concerns.
How serious is the interaction between Canagliflozin and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, renal function and potassium after starting canagliflozin, and reduce the diuretic or antihypertensive dose if volume depleted.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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