Drug interactions
Canagliflozin-metformin + Ceritinib
Severity: Moderate
Canagliflozin-metformin and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib can cause hyperglycemia in some patients, which may work against the glucose-lowering effect of the canagliflozin-metformin combination. Glycemic control may deteriorate during ceritinib treatment.
What this interaction means in plain words
Canagliflozin-metformin and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Ceritinib belongs to Oncology.
Why it happens
Ceritinib-associated hyperglycemia opposes the antihyperglycemic effect of canagliflozin and metformin (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c regularly during ceritinib therapy. Adjust the antidiabetic regimen if glycemic control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Ceritinib?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib can cause hyperglycemia in some patients, which may work against the glucose-lowering effect of the canagliflozin-metformin combination. Glycemic control may deteriorate during ceritinib treatment.
How serious is the interaction between Canagliflozin-metformin and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly during ceritinib therapy. Adjust the antidiabetic regimen if glycemic control worsens.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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