Drug interactions
Canagliflozin-metformin + Colesevelam
Severity: Minor
Canagliflozin-metformin and Colesevelam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam is a bile acid sequestrant that can bind some drugs in the gut. Its interaction with metformin is not clinically important, and it also modestly lowers glucose, so the two are often used together. Studies show no meaningful reduction in metformin exposure when given together, though extended-release metformin may be affected.
What this interaction means in plain words
Canagliflozin-metformin and Colesevelam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Colesevelam belongs to Endocrine.
Why it happens
Colesevelam may bind drug in the gastrointestinal tract and slightly reduce absorption of some co-administered agents, notably extended-release metformin.
What to do
No routine change is needed; monitor glycemic control when starting or stopping colesevelam. Separating doses by a few hours is a reasonable precaution.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Cyclosporine Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Colesevelam?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Colesevelam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam is a bile acid sequestrant that can bind some drugs in the gut. Its interaction with metformin is not clinically important, and it also modestly lowers glucose, so the two are often used together. Studies show no meaningful reduction in metformin exposure when given together, though extended-release metformin may be affected.
How serious is the interaction between Canagliflozin-metformin and Colesevelam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor glycemic control when starting or stopping colesevelam. Separating doses by a few hours is a reasonable precaution.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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