Drug interactions
Canagliflozin-metformin + Dolutegravir
Severity: Moderate
Canagliflozin-metformin and Dolutegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir inhibits renal OCT2 and MATE1, which raises metformin exposure. This increases the risk of metformin adverse effects, including gastrointestinal intolerance and, rarely, lactic acidosis.
What this interaction means in plain words
Canagliflozin-metformin and Dolutegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Dolutegravir belongs to Anti Virals.
Why it happens
Inhibition of renal organic cation transporters OCT2 and MATE1 by dolutegravir reduces metformin renal clearance.
What to do
Limit the total daily metformin dose to about 1000 mg when used with dolutegravir and monitor glycemic control and renal function. Readjust the metformin dose when dolutegravir is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Dolutegravir
Frequently asked questions
Can I take Canagliflozin-metformin with Dolutegravir?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Dolutegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolutegravir inhibits renal OCT2 and MATE1, which raises metformin exposure. This increases the risk of metformin adverse effects, including gastrointestinal intolerance and, rarely, lactic acidosis.
How serious is the interaction between Canagliflozin-metformin and Dolutegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the total daily metformin dose to about 1000 mg when used with dolutegravir and monitor glycemic control and renal function. Readjust the metformin dose when dolutegravir is started or stopped.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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