Drug interactions
Canagliflozin-metformin + Everolimus
Severity: Moderate
Canagliflozin-metformin and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus commonly causes hyperglycemia and hyperlipidemia, which can undermine glucose control in patients taking antidiabetic drugs. Doses of antidiabetics may need to be increased.
What this interaction means in plain words
Canagliflozin-metformin and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Everolimus belongs to Oncology.
Why it happens
mTOR inhibition impairs insulin signaling and beta-cell function, causing insulin resistance.
What to do
Monitor fasting glucose before and during everolimus therapy, and intensify antidiabetic treatment if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Everolimus?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus commonly causes hyperglycemia and hyperlipidemia, which can undermine glucose control in patients taking antidiabetic drugs. Doses of antidiabetics may need to be increased.
How serious is the interaction between Canagliflozin-metformin and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose before and during everolimus therapy, and intensify antidiabetic treatment if hyperglycemia develops.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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