Drug interactions
Canagliflozin-metformin + Glipizide
Severity: Moderate
Canagliflozin-metformin and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining canagliflozin and metformin with glipizide increases the risk of hypoglycemia through additive glucose lowering. Dose reduction of the sulfonylurea is often needed.
What this interaction means in plain words
Canagliflozin-metformin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Glipizide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with the sulfonylurea causing glucose-independent insulin release.
What to do
Consider lowering the glipizide dose when starting canagliflozin-metformin and monitor blood glucose closely. Counsel the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Glipizide
Frequently asked questions
Can I take Canagliflozin-metformin with Glipizide?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining canagliflozin and metformin with glipizide increases the risk of hypoglycemia through additive glucose lowering. Dose reduction of the sulfonylurea is often needed.
How serious is the interaction between Canagliflozin-metformin and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glipizide dose when starting canagliflozin-metformin and monitor blood glucose closely. Counsel the patient on recognizing and treating hypoglycemia.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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