Drug interactions
Canagliflozin-metformin + Lopinavir
Severity: Moderate
Canagliflozin-metformin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir-containing regimens have been linked to insulin resistance and hyperglycemia. Glycemic control on canagliflozin-metformin may worsen.
What this interaction means in plain words
Canagliflozin-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors can impair insulin-mediated glucose uptake and cause insulin resistance, which opposes the glucose-lowering effect of the antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c after lopinavir is started or changed. Increase antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Lopinavir?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir-containing regimens have been linked to insulin resistance and hyperglycemia. Glycemic control on canagliflozin-metformin may worsen.
How serious is the interaction between Canagliflozin-metformin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after lopinavir is started or changed. Increase antidiabetic therapy as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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