Drug interactions
Canagliflozin-metformin + Risperidone
Severity: Moderate
Canagliflozin-metformin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause weight gain and impaired glucose tolerance, which may reduce the glycemic control achieved with metformin and canagliflozin. Patients with diabetes may need closer glucose monitoring after the antipsychotic is started or the dose is changed.
What this interaction means in plain words
Canagliflozin-metformin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism, as atypical antipsychotics can induce insulin resistance and hyperglycemia.
What to do
Monitor fasting glucose and HbA1c after starting or changing risperidone, and intensify the antidiabetic regimen if control worsens. Reassess glycemia if the antipsychotic is later reduced or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Risperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Canagliflozin-metformin with Risperidone?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause weight gain and impaired glucose tolerance, which may reduce the glycemic control achieved with metformin and canagliflozin. Patients with diabetes may need closer glucose monitoring after the antipsychotic is started or the dose is changed.
How serious is the interaction between Canagliflozin-metformin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting or changing risperidone, and intensify the antidiabetic regimen if control worsens. Reassess glycemia if the antipsychotic is later reduced or stopped.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
