Drug interactions
Canakinumab + Mycophenolate mofetil
Severity: Moderate
Canakinumab and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canakinumab blocks interleukin-1 beta and is associated with a higher risk of serious infection. Adding mycophenolate further suppresses immune defenses.
What this interaction means in plain words
Canakinumab and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canakinumab belongs to Miscellaneous; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Additive immunosuppression via IL-1 beta blockade and inhibition of lymphocyte proliferation.
What to do
Screen for latent infections beforehand and monitor for signs of infection during combined therapy; stop canakinumab if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Canakinumab
- Adalimumab + Canakinumab Major
- Anakinra + Canakinumab Major
- Baricitinib + Canakinumab Major
- Basiliximab + Canakinumab Major
- Canakinumab + Etanercept Major
- Canakinumab + Golimumab Major
Frequently asked questions
Can I take Canakinumab with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Canakinumab and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canakinumab blocks interleukin-1 beta and is associated with a higher risk of serious infection. Adding mycophenolate further suppresses immune defenses.
How serious is the interaction between Canakinumab and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for latent infections beforehand and monitor for signs of infection during combined therapy; stop canakinumab if a serious infection develops.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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