Drug interactions
Candesartan + Digoxin
Severity: Minor
Candesartan and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan may raise potassium, while digoxin toxicity is influenced by potassium levels and renal function. The pairing is usually safe, but changes in renal function or electrolytes can alter digoxin effect. Candesartan has produced only small changes in digoxin levels.
What this interaction means in plain words
Candesartan and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
ARB-related shifts in potassium and renal function can alter digoxin sensitivity and clearance; no important direct pharmacokinetic interaction is established.
What to do
Check potassium and renal function periodically and measure digoxin levels if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Candesartan with Digoxin?
MediHelp rates the interaction as minor. Candesartan and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Candesartan may raise potassium, while digoxin toxicity is influenced by potassium levels and renal function. The pairing is usually safe, but changes in renal function or electrolytes can alter digoxin effect. Candesartan has produced only small changes in digoxin levels.
How serious is the interaction between Candesartan and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and renal function periodically and measure digoxin levels if toxicity is suspected.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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