Drug interactions
Candesartan + Hydrochlorothiazide
Severity: Minor
Candesartan and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination is widely used and gives additive blood pressure lowering. Excess volume depletion may cause hypotension or renal impairment, while the ARB partly offsets thiazide-induced potassium loss.
What this interaction means in plain words
Candesartan and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect, with angiotensin receptor blockade reducing aldosterone-mediated potassium loss.
What to do
Monitor blood pressure, renal function and potassium after initiation or dose changes. Reduce the diuretic if volume depletion occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Candesartan and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This combination is widely used and gives additive blood pressure lowering. Excess volume depletion may cause hypotension or renal impairment, while the ARB partly offsets thiazide-induced potassium loss.
How serious is the interaction between Candesartan and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium after initiation or dose changes. Reduce the diuretic if volume depletion occurs.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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