Drug interactions
Candesartan + Sotalol
Severity: Moderate
Candesartan and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and the effect may be additive. Candesartan can reduce renal function and raise potassium, and reduced renal clearance can increase sotalol exposure and torsades risk.
What this interaction means in plain words
Candesartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect; angiotensin receptor blockade may reduce glomerular filtration and cause hyperkalemia, altering sotalol clearance and cardiac repolarization.
What to do
Monitor blood pressure, heart rate, serum potassium, creatinine and QTc, especially at initiation and after dose changes. Adjust the sotalol dose according to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Sotalol?
MediHelp rates the interaction as moderate. Candesartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and the effect may be additive. Candesartan can reduce renal function and raise potassium, and reduced renal clearance can increase sotalol exposure and torsades risk.
How serious is the interaction between Candesartan and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, serum potassium, creatinine and QTc, especially at initiation and after dose changes. Adjust the sotalol dose according to creatinine clearance.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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