Drug interactions
Candesartan-hydrochlorothiazide + Carbamazepine
Severity: Moderate
Candesartan-hydrochlorothiazide and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and carbamazepine can each lower serum sodium, so combined use raises the risk of significant hyponatremia. Symptoms may include confusion, nausea and seizures.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Carbamazepine belongs to Central Nervous System.
Why it happens
Additive sodium-lowering effects from thiazide-induced renal sodium loss and carbamazepine-associated antidiuretic effects.
What to do
Monitor serum sodium at baseline and periodically, particularly in older adults. Switch the diuretic or adjust therapy if sodium drops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Carbamazepine?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide and carbamazepine can each lower serum sodium, so combined use raises the risk of significant hyponatremia. Symptoms may include confusion, nausea and seizures.
How serious is the interaction between Candesartan-hydrochlorothiazide and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium at baseline and periodically, particularly in older adults. Switch the diuretic or adjust therapy if sodium drops.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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