Drug interactions
Candesartan-hydrochlorothiazide + Corticotropin
Severity: Moderate
Candesartan-hydrochlorothiazide and Corticotropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates adrenal steroid release and can cause potassium loss and fluid retention. Together with hydrochlorothiazide it may produce hypokalemia and may also counteract blood pressure control.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Corticotropin belongs to Endocrine.
Why it happens
Corticotropin-induced mineralocorticoid and glucocorticoid excess adds to thiazide renal potassium wasting.
What to do
Monitor serum potassium and blood pressure during corticotropin courses, and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Corticotropin?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates adrenal steroid release and can cause potassium loss and fluid retention. Together with hydrochlorothiazide it may produce hypokalemia and may also counteract blood pressure control.
How serious is the interaction between Candesartan-hydrochlorothiazide and Corticotropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during corticotropin courses, and supplement potassium if needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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