Drug interactions
Candesartan-hydrochlorothiazide + Esmolol
Severity: Moderate
Candesartan-hydrochlorothiazide and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol may add to the blood pressure lowering effect of candesartan and hydrochlorothiazide, causing hypotension or bradycardia. Beta-blockade can also slightly impair cellular potassium uptake, which together with an ARB may contribute to a modest rise in potassium.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with minor beta-blocker impairment of cellular potassium uptake adding to ARB potassium retention.
What to do
Monitor blood pressure and heart rate closely during esmolol infusion in patients on this antihypertensive. Check potassium if renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Candesartan-hydrochlorothiazide and Esmolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Esmolol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol may add to the blood pressure lowering effect of candesartan and hydrochlorothiazide, causing hypotension or bradycardia. Beta-blockade can also slightly impair cellular potassium uptake, which together with an ARB may contribute to a modest rise in potassium.
How serious is the interaction between Candesartan-hydrochlorothiazide and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely during esmolol infusion in patients on this antihypertensive. Check potassium if renal function is impaired.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
