Drug interactions
Candesartan-hydrochlorothiazide + Furosemide
Severity: Moderate
Candesartan-hydrochlorothiazide and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide added to a thiazide and an ARB produces strong sequential diuresis that can cause hypovolemia, hypotension, acute kidney injury and electrolyte disturbances such as hyponatremia and hypokalemia. The ARB may partly offset potassium loss but increases the renal impact of volume depletion.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Additive natriuresis through loop and distal tubule blockade, combined with RAAS inhibition that limits renal compensation for volume loss.
What to do
Monitor blood pressure, weight, serum electrolytes and creatinine after starting or adjusting furosemide. Lower diuretic doses if volume depletion or renal decline occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Candesartan-hydrochlorothiazide and Furosemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Furosemide?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide added to a thiazide and an ARB produces strong sequential diuresis that can cause hypovolemia, hypotension, acute kidney injury and electrolyte disturbances such as hyponatremia and hypokalemia. The ARB may partly offset potassium loss but increases the renal impact of volume depletion.
How serious is the interaction between Candesartan-hydrochlorothiazide and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, serum electrolytes and creatinine after starting or adjusting furosemide. Lower diuretic doses if volume depletion or renal decline occurs.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
