Drug interactions
Candesartan-hydrochlorothiazide + Gentamicin
Severity: Moderate
Candesartan-hydrochlorothiazide and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin can cause renal tubular injury with magnesium and potassium wasting, and hydrochlorothiazide adds electrolyte loss and volume depletion. An ARB further reduces renal tolerance of hypovolemia, so the combination raises the risk of acute kidney injury and aminoglycoside toxicity.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Aminoglycoside nephrotoxicity is potentiated by diuretic-induced volume depletion and by ARB reduction of glomerular filtration pressure, with additive electrolyte wasting.
What to do
Monitor creatinine, potassium and magnesium, and gentamicin levels. Consider withholding the diuretic and ARB during acute illness or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Gentamicin?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin can cause renal tubular injury with magnesium and potassium wasting, and hydrochlorothiazide adds electrolyte loss and volume depletion. An ARB further reduces renal tolerance of hypovolemia, so the combination raises the risk of acute kidney injury and aminoglycoside toxicity.
How serious is the interaction between Candesartan-hydrochlorothiazide and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium and magnesium, and gentamicin levels. Consider withholding the diuretic and ARB during acute illness or volume depletion.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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