Drug interactions
Candesartan-hydrochlorothiazide + Labetalol
Severity: Minor
Candesartan-hydrochlorothiazide and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol and candesartan-hydrochlorothiazide are all antihypertensives, so combined use produces additive blood pressure lowering that can cause symptomatic hypotension. This is often an intended combination, but dose changes need care.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic lowering of blood pressure through alpha/beta blockade, AT1 blockade, and diuresis.
What to do
Monitor blood pressure and heart rate after starting or adjusting doses, and counsel patients about orthostatic dizziness. Avoid use in pregnancy because of ARB fetal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Labetalol?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labetalol and candesartan-hydrochlorothiazide are all antihypertensives, so combined use produces additive blood pressure lowering that can cause symptomatic hypotension. This is often an intended combination, but dose changes need care.
How serious is the interaction between Candesartan-hydrochlorothiazide and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or adjusting doses, and counsel patients about orthostatic dizziness. Avoid use in pregnancy because of ARB fetal toxicity.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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