Drug interactions
Candesartan-hydrochlorothiazide + Liraglutide
Severity: Minor
Candesartan-hydrochlorothiazide and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can worsen glucose tolerance and partially oppose the glucose-lowering effect of liraglutide. ARBs may slightly improve insulin sensitivity. Liraglutide-related vomiting or diarrhea may also cause volume depletion and kidney injury in patients on an ARB and diuretic.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Thiazide-induced reduction in insulin sensitivity and secretion opposes incretin effects, while GI fluid loss from liraglutide adds to diuretic and ARB renal risk.
What to do
Monitor glycemic control when starting or changing the thiazide dose. Advise adequate hydration and check renal function if GI symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Liraglutide?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can worsen glucose tolerance and partially oppose the glucose-lowering effect of liraglutide. ARBs may slightly improve insulin sensitivity. Liraglutide-related vomiting or diarrhea may also cause volume depletion and kidney injury in patients on an ARB and diuretic.
How serious is the interaction between Candesartan-hydrochlorothiazide and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting or changing the thiazide dose. Advise adequate hydration and check renal function if GI symptoms occur.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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