Drug interactions
Candesartan-hydrochlorothiazide + Lornoxicam
Severity: Moderate
Candesartan-hydrochlorothiazide and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam, like other NSAIDs, can reduce the antihypertensive effect of candesartan and hydrochlorothiazide. The triple combination of an NSAID, ARB, and diuretic increases the risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and causes sodium retention in the setting of RAS blockade and diuresis.
What to do
Use the lowest effective NSAID dose for the shortest time and keep the patient well hydrated. Monitor blood pressure, creatinine, and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Lornoxicam?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam, like other NSAIDs, can reduce the antihypertensive effect of candesartan and hydrochlorothiazide. The triple combination of an NSAID, ARB, and diuretic increases the risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Candesartan-hydrochlorothiazide and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and keep the patient well hydrated. Monitor blood pressure, creatinine, and potassium.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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