Drug interactions
Candesartan-hydrochlorothiazide + Lurasidone
Severity: Moderate
Candesartan-hydrochlorothiazide and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-adrenergic blocking activity that can add to the blood pressure lowering of candesartan and hydrochlorothiazide. This may cause orthostatic hypotension, dizziness, and falls.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from antipsychotic alpha-1 adrenergic antagonism combined with ARB and diuretic action.
What to do
Monitor blood pressure, particularly at initiation and dose changes, and reduce the antihypertensive dose if hypotension occurs. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Lurasidone?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-adrenergic blocking activity that can add to the blood pressure lowering of candesartan and hydrochlorothiazide. This may cause orthostatic hypotension, dizziness, and falls.
How serious is the interaction between Candesartan-hydrochlorothiazide and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, particularly at initiation and dose changes, and reduce the antihypertensive dose if hypotension occurs. Advise patients to rise slowly.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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