Drug interactions
Candesartan-hydrochlorothiazide + Mefenamic acid
Severity: Moderate
Candesartan-hydrochlorothiazide and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid can weaken the antihypertensive effect of candesartan and hydrochlorothiazide. The combination also raises the risk of acute kidney injury and hyperkalemia, especially in elderly or dehydrated patients.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium retention and reduces renal perfusion in the presence of ARB and diuretic therapy.
What to do
Limit NSAID dose and duration and maintain hydration. Monitor blood pressure, creatinine, and potassium, or use paracetamol instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Mefenamic acid?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid can weaken the antihypertensive effect of candesartan and hydrochlorothiazide. The combination also raises the risk of acute kidney injury and hyperkalemia, especially in elderly or dehydrated patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit NSAID dose and duration and maintain hydration. Monitor blood pressure, creatinine, and potassium, or use paracetamol instead.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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