Drug interactions
Candesartan-hydrochlorothiazide + Metoprolol
Severity: Minor
Candesartan-hydrochlorothiazide and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol adds to the blood pressure lowering of candesartan and hydrochlorothiazide, which is often intended but can cause hypotension or bradycardia. Beta blockers may also slightly worsen glucose and lipid effects of thiazides.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects via beta-1 blockade, AT1 receptor blockade, and diuresis.
What to do
Monitor blood pressure and heart rate when starting or titrating. Avoid ARB use in pregnancy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Metoprolol?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoprolol adds to the blood pressure lowering of candesartan and hydrochlorothiazide, which is often intended but can cause hypotension or bradycardia. Beta blockers may also slightly worsen glucose and lipid effects of thiazides.
How serious is the interaction between Candesartan-hydrochlorothiazide and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating. Avoid ARB use in pregnancy.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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