Drug interactions
Candesartan-hydrochlorothiazide + Nabumetone
Severity: Moderate
Candesartan-hydrochlorothiazide and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabumetone can diminish the antihypertensive effect of candesartan and hydrochlorothiazide. Together they increase the risk of kidney function decline and hyperkalemia, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and causes sodium retention under RAS blockade and diuresis.
What to do
Use the lowest effective dose for the shortest duration and maintain hydration. Monitor blood pressure, creatinine, and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Nabumetone?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabumetone can diminish the antihypertensive effect of candesartan and hydrochlorothiazide. Together they increase the risk of kidney function decline and hyperkalemia, especially in elderly or volume-depleted patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest duration and maintain hydration. Monitor blood pressure, creatinine, and potassium.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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