Drug interactions
Candesartan-hydrochlorothiazide + Piroxicam
Severity: Moderate
Candesartan-hydrochlorothiazide and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam can weaken the blood pressure control of candesartan and hydrochlorothiazide. Together they increase the risk of renal function decline and hyperkalemia, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID prostaglandin inhibition reduces renal blood flow and promotes sodium and water retention with RAS blockade and diuresis.
What to do
Use the lowest effective dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine, and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Piroxicam?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam can weaken the blood pressure control of candesartan and hydrochlorothiazide. Together they increase the risk of renal function decline and hyperkalemia, particularly in elderly or volume-depleted patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine, and potassium.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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