Drug interactions
Candesartan-hydrochlorothiazide + Tizanidine
Severity: Moderate
Candesartan-hydrochlorothiazide and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is a central alpha-2 agonist that lowers blood pressure and can cause hypotension and bradycardia. When used with candesartan and hydrochlorothiazide, the hypotensive effect is additive, and dizziness or syncope may occur.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive antihypertensive effect via central sympatholysis and RAAS blockade plus diuresis.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing tizanidine. Reduce the tizanidine dose or adjust antihypertensives if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Tizanidine?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is a central alpha-2 agonist that lowers blood pressure and can cause hypotension and bradycardia. When used with candesartan and hydrochlorothiazide, the hypotensive effect is additive, and dizziness or syncope may occur.
How serious is the interaction between Candesartan-hydrochlorothiazide and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing tizanidine. Reduce the tizanidine dose or adjust antihypertensives if hypotension develops.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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