Drug interactions
Candesartan-hydrochlorothiazide + Trientine
Severity: Minor
Candesartan-hydrochlorothiazide and Trientine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics increase urinary copper loss, and trientine also promotes copper excretion, so the effect on copper balance is uncertain. Clinical significance is unclear and probably small.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Trientine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Trientine belongs to Miscellaneous.
Why it happens
Mechanism not well established; thiazide-increased renal clearance of trientine has been proposed.
What to do
Monitor urinary copper and clinical response to trientine in Wilson disease when a thiazide is added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Trientine
- Calcium + Trientine Moderate
- Carbonyl iron + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Ferrous sulfate + Trientine Moderate
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Trientine?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Trientine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics increase urinary copper loss, and trientine also promotes copper excretion, so the effect on copper balance is uncertain. Clinical significance is unclear and probably small.
How serious is the interaction between Candesartan-hydrochlorothiazide and Trientine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary copper and clinical response to trientine in Wilson disease when a thiazide is added.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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