Drug interactions
Cannabidiol + Digoxin
Severity: Moderate
Cannabidiol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits P-glycoprotein in vitro and may increase digoxin concentrations. Raised digoxin levels could lead to toxicity given its narrow therapeutic window.
What this interaction means in plain words
Cannabidiol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Digoxin belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition reduces digoxin efflux and clearance.
What to do
Monitor digoxin levels and toxicity signs when starting or stopping cannabidiol; reduce the digoxin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Digoxin?
MediHelp rates the interaction as moderate. Cannabidiol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits P-glycoprotein in vitro and may increase digoxin concentrations. Raised digoxin levels could lead to toxicity given its narrow therapeutic window.
How serious is the interaction between Cannabidiol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and toxicity signs when starting or stopping cannabidiol; reduce the digoxin dose if needed.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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