Drug interactions
Cannabidiol + Duloxetine
Severity: Moderate
Cannabidiol and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is metabolised by CYP1A2 and CYP2D6, and cannabidiol can affect these enzymes, so duloxetine exposure could change. Cannabidiol also causes somnolence which may add to duloxetine side effects.
What this interaction means in plain words
Cannabidiol and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Cannabidiol modulates CYP1A2 and CYP2D6 activity, altering duloxetine clearance.
What to do
Monitor clinical response and adverse effects such as nausea, dizziness and sedation when starting or stopping cannabidiol. Adjust duloxetine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cannabidiol and Duloxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Duloxetine?
MediHelp rates the interaction as moderate. Cannabidiol and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine is metabolised by CYP1A2 and CYP2D6, and cannabidiol can affect these enzymes, so duloxetine exposure could change. Cannabidiol also causes somnolence which may add to duloxetine side effects.
How serious is the interaction between Cannabidiol and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects such as nausea, dizziness and sedation when starting or stopping cannabidiol. Adjust duloxetine dose if needed.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
