Drug interactions
Cannabidiol + Esomeprazole
Severity: Moderate
Cannabidiol and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19 and can raise esomeprazole levels, and esomeprazole may also raise cannabidiol exposure. Increased adverse effects such as sedation may occur.
What this interaction means in plain words
Cannabidiol and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Competing CYP2C19 metabolism with cannabidiol inhibiting CYP2C19.
What to do
Monitor for sedation and other adverse effects and reduce the cannabidiol dose if poorly tolerated. Esomeprazole dose reduction is rarely needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Esomeprazole?
MediHelp rates the interaction as moderate. Cannabidiol and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19 and can raise esomeprazole levels, and esomeprazole may also raise cannabidiol exposure. Increased adverse effects such as sedation may occur.
How serious is the interaction between Cannabidiol and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and other adverse effects and reduce the cannabidiol dose if poorly tolerated. Esomeprazole dose reduction is rarely needed.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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