Drug interactions
Cannabidiol + Estradiol
Severity: Minor
Cannabidiol and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can affect CYP enzymes and might alter estradiol exposure, but estradiol is cleared mainly through CYP3A4 and conjugation rather than CYP1A2. The clinical significance is likely small.
What this interaction means in plain words
Cannabidiol and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Estradiol belongs to Endocrine.
Why it happens
Cannabidiol may inhibit or induce CYP1A2, which contributes only minor to estradiol hydroxylation.
What to do
No empirical dose change is required; monitor for changes in symptom control or estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Estradiol?
MediHelp rates the interaction as minor. Cannabidiol and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol can affect CYP enzymes and might alter estradiol exposure, but estradiol is cleared mainly through CYP3A4 and conjugation rather than CYP1A2. The clinical significance is likely small.
How serious is the interaction between Cannabidiol and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required; monitor for changes in symptom control or estrogenic adverse effects.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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