Drug interactions
Cannabidiol + Gemfibrozil
Severity: Moderate
Cannabidiol and Gemfibrozil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may inhibit CYP2C19, which contributes to cannabidiol metabolism, raising cannabidiol levels and adverse effects such as somnolence and transaminase elevation. Cannabidiol may in turn inhibit UGT enzymes involved in gemfibrozil glucuronidation.
What this interaction means in plain words
Cannabidiol and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Gemfibrozil belongs to Cardiovascular.
Why it happens
Bidirectional inhibition of metabolism: CYP2C19 inhibition by gemfibrozil and possible UGT inhibition by cannabidiol.
What to do
Monitor for sedation and liver enzyme elevations, and consider reducing the cannabidiol dose if adverse effects occur. Watch for gemfibrozil adverse effects such as myalgia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Gemfibrozil?
MediHelp rates the interaction as moderate. Cannabidiol and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may inhibit CYP2C19, which contributes to cannabidiol metabolism, raising cannabidiol levels and adverse effects such as somnolence and transaminase elevation. Cannabidiol may in turn inhibit UGT enzymes involved in gemfibrozil glucuronidation.
How serious is the interaction between Cannabidiol and Gemfibrozil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and liver enzyme elevations, and consider reducing the cannabidiol dose if adverse effects occur. Watch for gemfibrozil adverse effects such as myalgia.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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