Drug interactions
Cannabidiol + Lacosamide
Severity: Minor
Cannabidiol and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19 and CYP2C9 in vitro and might modestly raise lacosamide exposure. Both drugs can cause dizziness and somnolence, so additive CNS effects are also possible.
What this interaction means in plain words
Cannabidiol and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Lacosamide belongs to Central Nervous System.
Why it happens
Cannabidiol inhibits CYP2C19/CYP2C9, reducing lacosamide metabolism, with additive CNS depression.
What to do
Monitor for dizziness, somnolence and PR-interval related symptoms. Reduce lacosamide dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Lacosamide?
MediHelp rates the interaction as minor. Cannabidiol and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol inhibits CYP2C19 and CYP2C9 in vitro and might modestly raise lacosamide exposure. Both drugs can cause dizziness and somnolence, so additive CNS effects are also possible.
How serious is the interaction between Cannabidiol and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, somnolence and PR-interval related symptoms. Reduce lacosamide dose if adverse effects emerge.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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