Drug interactions
Cannabidiol + Loratadine
Severity: Minor
Cannabidiol and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loratadine is metabolized partly by CYP2C19 and may be a weak inhibitor, while cannabidiol is cleared by CYP2C19 and CYP3A4. Any rise in cannabidiol exposure is likely small and would show as more drowsiness, diarrhea or liver enzyme elevation.
What this interaction means in plain words
Cannabidiol and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
Possible weak inhibition of CYP2C19-mediated cannabidiol metabolism.
What to do
Monitor for sedation, gastrointestinal effects and liver enzymes as per cannabidiol labeling. Lower the cannabidiol dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Loratadine?
MediHelp rates the interaction as minor. Cannabidiol and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loratadine is metabolized partly by CYP2C19 and may be a weak inhibitor, while cannabidiol is cleared by CYP2C19 and CYP3A4. Any rise in cannabidiol exposure is likely small and would show as more drowsiness, diarrhea or liver enzyme elevation.
How serious is the interaction between Cannabidiol and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, gastrointestinal effects and liver enzymes as per cannabidiol labeling. Lower the cannabidiol dose if adverse effects emerge.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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