Drug interactions
Cannabidiol + Mirtazapine
Severity: Moderate
Cannabidiol and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can alter CYP1A2 and other enzyme activity, which may change mirtazapine exposure unpredictably. Cannabidiol also adds to sedation and drowsiness.
What this interaction means in plain words
Cannabidiol and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Cannabidiol may inhibit or induce CYP enzymes involved in mirtazapine metabolism, plus additive CNS depression.
What to do
Monitor for excess sedation or reduced antidepressant response and adjust the mirtazapine dose accordingly. Advise patients about impaired driving and alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Mirtazapine?
MediHelp rates the interaction as moderate. Cannabidiol and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can alter CYP1A2 and other enzyme activity, which may change mirtazapine exposure unpredictably. Cannabidiol also adds to sedation and drowsiness.
How serious is the interaction between Cannabidiol and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation or reduced antidepressant response and adjust the mirtazapine dose accordingly. Advise patients about impaired driving and alertness.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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