Drug interactions
Cannabidiol + Modafinil
Severity: Minor
Cannabidiol and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs interact with CYP2C19 and cannabidiol inhibits it, so modafinil exposure may rise. Modafinil may in turn modestly raise cannabidiol levels, increasing sedation or other adverse effects.
What this interaction means in plain words
Cannabidiol and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Mutual CYP2C19 inhibition affecting metabolism of both drugs.
What to do
Monitor for adverse effects such as somnolence, insomnia, anxiety and raised liver enzymes. Reduce the dose of either drug if effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Modafinil?
MediHelp rates the interaction as minor. Cannabidiol and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs interact with CYP2C19 and cannabidiol inhibits it, so modafinil exposure may rise. Modafinil may in turn modestly raise cannabidiol levels, increasing sedation or other adverse effects.
How serious is the interaction between Cannabidiol and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as somnolence, insomnia, anxiety and raised liver enzymes. Reduce the dose of either drug if effects occur.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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