Drug interactions
Cannabidiol + Stiripentol
Severity: Moderate
Cannabidiol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may raise stiripentol concentrations, which could increase stiripentol adverse effects such as somnolence and reduced appetite. The magnitude of the effect is uncertain.
What this interaction means in plain words
Cannabidiol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Probable inhibition of CYP-mediated stiripentol metabolism by cannabidiol, although the exact mechanism is unclear.
What to do
Monitor for sedation, appetite loss and weight change. Reduce the stiripentol dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Cannabidiol with Stiripentol?
MediHelp rates the interaction as moderate. Cannabidiol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may raise stiripentol concentrations, which could increase stiripentol adverse effects such as somnolence and reduced appetite. The magnitude of the effect is uncertain.
How serious is the interaction between Cannabidiol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, appetite loss and weight change. Reduce the stiripentol dose if adverse effects arise.
What other medicines interact with Cannabidiol?
MediHelp also lists interactions of Cannabidiol with, for example, Phenytoin, Sodium valproate, Tacrolimus. The full list is on the Cannabidiol page.
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