Drug interactions
Cannabidiol + Trimipramine
Severity: Moderate
Cannabidiol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19 and may raise trimipramine concentrations, which depend partly on this enzyme. Higher exposure may increase sedation, anticholinergic effects and cardiac toxicity.
What this interaction means in plain words
Cannabidiol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated metabolism of trimipramine.
What to do
Monitor for tricyclic adverse effects and consider reducing the trimipramine dose. Use drug level monitoring or an ECG if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Trimipramine?
MediHelp rates the interaction as moderate. Cannabidiol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19 and may raise trimipramine concentrations, which depend partly on this enzyme. Higher exposure may increase sedation, anticholinergic effects and cardiac toxicity.
How serious is the interaction between Cannabidiol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider reducing the trimipramine dose. Use drug level monitoring or an ECG if toxicity is suspected.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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